Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection.

نویسندگان

  • Adam R Hersperger
  • Nicholas A Siciliano
  • Brian C DeHaven
  • Adam E Snook
  • Laurence C Eisenlohr
چکیده

We assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest protection. Humoral immunity and resident-memory T cells notwithstanding, several approaches revealed that circulating, memory CD8(+) T cells primed via scarification were functionally superior and conferred enhanced virus control. Immunization via the epithelial route warrants further investigation, as it may also provide enhanced defense against other infectious agents.

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عنوان ژورنال:
  • Journal of virology

دوره 88 16  شماره 

صفحات  -

تاریخ انتشار 2014